Bioprocess Engineering: Basic Concepts 2nd Edition by Michael L. Shuler and Fikret Kargi updates the main introductory textbook on biochemical and bioprocess engineering to reflect advances which can be reworking the sphere -- from genomics to cellular engineering, modeling to nonconventional biological systems. It introduces methods with wide applicability in pharmaceuticals, biologics, medicine, environmental engineering, and beyond.
It's a comprehensive replace of the world's leading introductory textbook on biochemical and bioprocess engineering. Authors evaluate the relevant fundamentals of biochemistry, microbiology, and molecular biology, introducing key principles that enable bioprocess engineers to achieve constant control over biological activity.
This edition displays powerful advances which might be remodeling the sector, ranging from genetic sequencing to new techniques for producing proteins from recombinant DNA. It introduces methods with broad application to the production of pharmaceuticals, biologics, and commodities; to medical purposes comparable to tissue engineering and gene remedy; and for solving crucial environmental problems.
This new edition includes essential biological basics: microorganism structure and functions, major metabolic pathways, enzymes, microbial genetics, kinetics, and stoichiometry of growth with new coverage of posttranslational processing of proteins-an essential technique for manufacturing therapeutic proteins, in-depth coverage of animal cell culture processes, new coverage of noncarbohydrate metabolism, functional genomics and cellular engineering: concepts, techniques, and applications.
This edition contains a new section in the first chapter alerting students to the regulatory issues that constrain bioprocess design and modification. We believe students need to be aware of these industrially critical issues. Part 2, "An Overview of Biological Basics," has been updated throughout and expanded. Greater emphasis is given now to posttranslational processing of proteins, as this is a key issue in choice of bioprocessing strategies to make therapeutic proteins.
Basic processes in animal cells are more completely described, since animal cell culture is now an established commercial bioprocess technology. Chapter 5 is made more complete by introduction of a section on noncarbohydrate metabolism. Key concepts in functional genomics have been added to prepare students to understand the impact of these emerging ideas and technologies on bioprocesses.
In Part 3, "Engineering Principles for Bioprocesses," greater attention is given to issues associated with animal cell bioreactors. The discussion of chromatographic processes is expanded. In Part 4, "Applications to Nonconventional Biological Systems," the material has been rearranged and updated and a new chapter added. These changes are evident in the chapters on animal and plant cell culture. Particularly important is the expanded discussion on choice of host-vector systems for production of proteins from recombinant DNA technology.
Coverage of two areas of increasing importance to bioprocess engineers, metabolic and protein engineering, has been expanded. A new chapter on biomedical applications illustrates how approaches to bioprocess engineering are relevant to problems typically considered to be biomedical engineering. The chapter on mixed cultures has been extended to cover advanced waste-water treatment processes. An appendix providing descriptive overviews of some traditional bioprocesses is now included.
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